Chronic kidney disease (CKD) is associated with a premature ageing-like phenotype including increased prevalence of cardiovascular disease, osteoporosis, and skeletal muscle atrophy.(1,2) Muscle atrophy is one of the frequent complications in patients with CKD, and is related with CKD prognosis and mortality.(3) In CKD pathogenesis, the activation of proteolytic pathways such as the ubiquitin proteasome system (UPS) and caspase-3 can be primary mechanism of skeletal muscle atrophy.(2). Here, CASP3 is linked to chronic kidney disease.