On the other hand, it is well-known that CKD patients show hyperphosphatemia.(1) We have recently indicated that elevation of extracellular phosphorus level reduces SCD activity and its protein and mRNA levels in human vascular smooth muscle cells, and rats fed with high phosphorus diets decline the levels of SCD mRNA expression in white adipose tissue compared with control diets.(26) In fact, high phosphorus loading in C2C12 myotubes decreased the levels of mRNA expressionof SCD1 (data not shown). This evidence concerns the gene SCD and chronic kidney disease.