Also, palmitic acid dose-dependently lead to a decrease in number, width, and length of myotubes.(17) Interestingly, CKD patients had higher levels of serum stearic acid but not oleic acid, as well as a consequent lower SCD activity compared with subjects with normal kidney function.(15) However, it has not been clarifies that the roles of imbalance between SFAs and MUFAs in ER stress and muscle atrophy in CKD. The gene discussed is SCD; the disease is chronic kidney disease.