Moreover, NUPR1 maintains autolysosomal efflux and is required for the progression of non-small cell lung cancer.(15) However, Tang et al.(30) have shown that NUPR1 is activated, and mediates intestinal epithelial cells death via increasing autophagy-related gene in response to Shiga toxins toxicity. This evidence concerns the gene NUPR1 and non-small cell lung carcinoma.