However, other previous studies confirmed NAC inhibited anti-tumor effect of some chemical agents isolated from the plant, such as britannin,(33) Umbilicaria esculenta,(34) and cryptotanshinone.(35) Consistent with those previous studies, NAC also abolished quercetin-induced NUPR1-depended autophagic cell death in OS cells both in vitro and in vivo. Here, NUPR1 is linked to neoplasm.