The Sebastian Weis group reported that NUPR1 deficiency increases cellular ROS in mouse embryonic fibroblasts.(31) Moreover, NUPR1 downregulation induces mitochondrial failure with loss of the mitochondrial membrane potential, a strong increase in ROS production and promotion of pancreatic cancer cell death.(16) In the present study, quercetin exposure was found to initiate ROS elevation, and inhibiting ROS efficiently decreased NUPR1 expression, followed by a reduction of autophagy-related genes expression. The gene discussed is NUPR1; the disease is familial pancreatic carcinoma.