Many infected patients experienced lymphopenia in which the decrease of primary immune cell counts was related to the severity of disease.(12–14) It commended that in patients with COVID-19, more attention should be paid to lymphopenia or an obviously decrease in the number of CD4 and CD8 T cells.(21) In our study, lower counts of lymphocyte and CD4 and CD8 T cell were observed in patients with moderate-severe malnutrition, indicating a damaged immune function. The gene discussed is CD8A; the disease is COVID-19.