We found that overexpression SLC25A26 facilitated the expression of p16, p21 and HMGA1 both in protein and mRNA levels (Supplementary Fig. 2C–F), while SLC25A26 siRNA significantly inhibited the ability of CTB to induce HCC cells senescence (Fig. 4C–F). Here, CDKN2A is linked to hepatocellular carcinoma.