CX3CL1 and Hodgkins lymphoma: Thus, a plausible speculation is that microglia in the auditory region of the brain are activated by disruption of the microglia–neuron communication (such as a fractalkine signaling deficiency [102]) and that the activated microglia in the auditory region of the brain may play a pivotal role in remodeling during the process of circuit plasticity following acquired HL, including activity-dependent synaptogenesis and synapse elimination [13, 16, 103–105].