The protein levels of p‐STAT3 (Tyr705), N‐cadherin, E‐cadherin, vimentin, MMP‐13, and MMP‐3 in the tumor tissues grown from HeLa cells were determined through IHC and Western blot to examine the effects of RES on STAT3 phosphorylation, EMT, and cervical cancer cell invasion. The gene discussed is CDH2; the disease is cervical cancer.