HeLa and SiHa cells were treated with RES and S3I201 or AG490, and the expression levels of N‐cadherin, E‐cadherin, vimentin, MMP‐3, and MMP‐13 were examined to confirm that the role of STAT3 phosphorylation was inhibited by RES on the invasion potential of cervical cancer cells. The gene discussed is CDH1; the disease is cervical cancer.