RES inhibits STAT3 Tyr705 phosphorylation in ovarian cancer,20, 21 pancreatic cancer,22 head and neck tumor,23 osteosarcoma,24 colorectal cancer,25 colon cancer,22, 23, 24, 25, 26 and STAT3S727 phosphorylation in head and neck tumor and colorectal cancer.23, 25. The gene discussed is STAT3; the disease is osteosarcoma.