IL‐6 was used to activate STAT3 signaling pathway in HeLa and SiHa cells, and the expression of N‐cadherin, E‐cadherin, vimentin, MMP‐3, and MMP‐13 were examined to confirm the activation of the STAT3 signaling pathway to promote the invasion potential of cervical cancer cells. The gene discussed is CDH2; the disease is cervical carcinoma.