The results in primary tumors and the ability of antago-miR-24-3p-EVs to recapitulate anti-IL-3R-EV action in vitro led us to determine the impact of circulating anti-IL-3R-EVs/antago-miR-24-3p-EVs in preventing the formation of lung metastasis generated by tumor cell intravenous injection. The gene discussed is IL3RA; the disease is neoplasm.