The levels of Katnal1 and Trpv4 in hippocampus of CCH group were significantly up-regulated than in that of sham group (P<0.01), whereas Mgam and Cpg1 in hippocampus of CCH group were significantly down-regulated than in that of sham group (P<0.01) (Figure 5B). This evidence concerns the gene KATNAL1 and columnar cell hyperplasia of the breast.