AKT1 and cancer: KEGG pathway analysis showed that the top 10 deferentially-enriched KEGG pathways related to dysregulated mRNAs were involved in tryptophan metabolism, thyroid hormone synthesis, pertussis, cholinergic synapse, osteoclast differentiation, the Jak-STAT signaling pathway, phagosome, the PI3K-Akt signaling pathway, proteoglycans in cancer, and cytokine-cytokine receptor interaction (Figure 10D).