HES1 and neoplasm: Then, the proteins were extracted from the tumor tissues, and the expression levels of caspase-3, BAX and E-cadherin increased, while the expression of Bcl-2, EZH2, N1CD, Hes1, MMP-9 and vimentin were inhibited in tumors from miR-124-exo and 5-FU co-treated mice, when compared to 5-FU treatment alone (Figure 10C, 10D), which was consistent with that in the in vitro experiments.