In the present study, it was found that the miR-124 expression in pancreatic cancer or pancreatic cancer cell lines all decreased, and overexpression of miR-124 delivered by BM-MSC derived exosomes suppressed cell viability, invasion and migration, as well as induced cell apoptosis in pancreatic cancer through regulating EZH2. The gene discussed is EZH2; the disease is familial pancreatic carcinoma.