CD8A and Sepsis: However, despite numerical recovery of T-cells, CD4+ T-cells have impaired immune responses to ex-vivo stimulation by Aspergillus antigen [35] and memory CD8+ T-cells have decreased antigen sensitivity (as demonstrated in post-sepsis mice), [36] while stimulation of whole-blood from sepsis survivors with T-cell activator (α-CD3/28) leads to a lower IFNγ secretion as compared to healthy controls [24].