Altered DNA methylation and histone modifications are observed in human patients and murine models post-sepsis and result in repressed expression of immune-related genes encoding TNFα, IL-1ß, IL-12, and chemokine ligand 2 (CXCL-2/MIP2-α) in macrophages and dendritic cells, [28], [29], [30] and interferon gamma (IFNγ) in CD4+ T-cells [31]. This evidence concerns the gene TNF and Sepsis.