We used a two‐sample MR framework to examine the associations of specific adipokines (ie, adiponectin, leptin, sOB‐R and PAI‐1) with five obesity‐related cancers using genetic variants associated with adipokines concentrations from published genome‐wide association studies (GWAS).15, 16, 17, 18, 19. The gene discussed is SERPINE1; the disease is obesity due to melanocortin 4 receptor deficiency.