PAI‐1 concentration was not associated with risks of colorectal cancer (IVW OR per 1 ng/mL increase in log‐transformed PAI‐1 concentration: 1.01 [95% CI = 0.86‐1.19]; P = .92), pancreatic cancer (OR = 1.13 [95% CI = 0.73‐1.76]; P = .58), RCC (OR = 1.09 [95% CI = 0.78‐1.52]; P = 0.62) and ovarian cancer (OR = 1.22 [95% CI = 0.95‐1.55]; P = .11) (Figure 1 and Table S6). This evidence concerns the gene SERPINE1 and colorectal cancer.