The effect estimates for adiponectin and colorectal cancer were also slightly attenuated after the exclusion of variants associated with adiposity measures/insulin [overall colorectal cancer (OR = 0.92 [95% CI = 0.84‐1.01]; P = .09) (data not shown) or in a multivariable MR analysis accounting for BMI (overall colorectal cancer; OR = 0.92 [95% CI = 0.84‐1.01]; P = .1) (Table S3). This evidence concerns the gene INS and colorectal cancer.