In the IVW models, we found an inverse association between adiponectin and risks of colorectal cancer (OR per 1 μg/mL increment in adiponectin concentrations: 0.90 (95% confidence interval [CI] = 0.84‐0.97); P = .01), with similar association found for men and women, colon cancer and rectal cancer (Figure 1 and Table S2). This evidence concerns the gene ADIPOQ and rectal cancer.