On the other hand, Barceló et al. [29] found no difference in cytokine expression by circulating CD8 + T lymphocytes in COPD or controls whereas Barcyzk et al. [30] reported that the number of IL-4 producing CD8 + T lymphocytes was lower in the peripheral blood than in BAL. The gene discussed is CD8A; the disease is chronic obstructive pulmonary disease.