Hep3B cells co‐transfected with Linc‐smad7 overexpression vector and sh‐SIRT6 vector generated smaller tumours (Lv‐Linc‐smad7+shSIRT6 group) than Hep3B cells only transfected with the Linc‐smad7 overexpression vector (p < 0.05, Figure 7D and E). This evidence concerns the gene SIRT6 and neoplasm.