Strikingly, one SA sample showed strong and diffuse staining of the fibroblasts of the tumoral stroma and predominantly negative staining of the tumor cells; this staining pattern resembled the caveolin-1 immunostaining pattern of cancer-associated fibroblasts (CAFs) in the stroma of some malignant tumors, such as breast, colorectal and kidney cancer and metastatic melanomas. The gene discussed is CAV1; the disease is metastatic melanoma.