However, Ohlsson et al suggest that serum zonulin might rather be a biomarker for low‐grade inflammation than for IP, because zonulin is identical to prehaptoglobin‐2, not enterocyte specific and associated with overweight, obesity and hyperlipidemia.10, 11, 33, 34. Here, HP is linked to obesity due to melanocortin 4 receptor deficiency.