Since, for various malignancies, including CRC, TRIP13 is associated with CIN, aneuploidy, and poor prognosis, the present study focused on identifying its downstream targets and its involvement in WNT/β‐catenin pathways and EGFR activation, which are responsible for CRC growth and metastasis. This evidence concerns the gene TRIP13 and cervical squamous intraepithelial neoplasia.