Furthermore, TRIP13 knockdown has not decreased the protein levels of PNPT1 (Fig. 6J) while PNPT1 knockdown resulted in decreased levels of TRIP13 protein (Fig. 6K), suggesting that as an interacting partner, PNPT1 could be regulating TRIP13 in CRC cells. This evidence concerns the gene PNPT1 and colorectal carcinoma.