As the Y402H mutation of the complement factor H (CFH) is the greatest genetic predictor of AMD development and severity [27], combinational suppression of miR-155 and miR-146a may be of particular interest due to their partially overlapping binging sites in the CFH mRNA 3′ untranslated region (UTR) [24, 28]. Here, CFH is linked to age-related macular degeneration.