The median pg/mL serum levels of soluble TNFR1 and TNFR2 were 3.4-fold and 6.8-fold lower in OSA patients relative to control subjects, p = 4.1 × 10−8 and 1.8 × 10−13, respectively (Fig. 1c and c, Table 2). This evidence concerns the gene TNFRSF1A and obstructive sleep apnea syndrome.