Altered levels of the membrane and/or soluble isoforms of gp130 and IL6R have been reported in the serum, cerebral fluid, and/or brain of patients with Alzheimer disease [112–114], amyotrophic lateral sclerosis [70], multiple sclerosis [71], and schizophrenia and bipolar disorder [72, 115]. This evidence concerns the gene IL6R and bipolar disorder.