By restoration of the Hoxb13 expression in SUV-OE AML cells (Fig. 7b), we found an accelerated leukemia progression in SUV-OE AML mice, indicating that Hoxb13 restoration abolished the effect of SUV-OE on prolonged survival of MLL-r AML mice (Fig. 7c). This evidence concerns the gene KMT2A and acute myeloid leukemia.