We analyzed 1305 African-American MS cases and 1155 African-American controls and found that the 2005 admixture mapping signal could be fully explained by two variants that are strongly correlated with haplotypes previously linked to MS in people of European ancestry: one in the CD58 gene located on the p-arm near the centromere and one in the FCRL3 gene on the q-arm near the centromere. The gene discussed is CD58; the disease is myeloid sarcoma.