Lastly, the rs12025416 risk allele found in this study (A/T allele) was found to have higher IL-6 and TNF-alpha macrophage response to Candida exposure31, suggesting that another possible mechanism for increased MS risk may be related to a pro-inflammatory state induced by a stronger TNF-alpha response, possibly through decreased CD58 stimulation on macrophages leading them to take on a pro-inflammatory state, consistent with other MS susceptibility variants showing an enrichment in the TNF-alpha pathway15,16. The gene discussed is CD58; the disease is myeloid sarcoma.