NFKB1 and gastric cancer: Future studies integrating data from ChIP-seq-based surveys (for example, by pull-down of R-loop-associated DNA with the RNA/DNA hybrid-specific antibody S9.6) with transcriptional profiling and mutational data for gastric cancer and its precursor lesions will reveal whether certain heavily transcribed (NF-κB-regulated) loci are particularly prone to R-loop-dependent DNA damage and mutagenesis.