These subtypes were EBV-positive gastric cancer (characterized by the presence of EBV genes and transcripts, a very low mutational burden and PIK3CA mutations), microsatellite-instable gastric cancer (high mutational burden, MSI high), chromosomally instable gastric cancer (with large numbers of copy number variations and a high mutational burden, and ubiquitous TP53 mutations) and genomically stable gastric cancer (low mutational burden, diffuse type by histology, early-onset, RHOA and ARHGAP6/26 somatic genomic alterations)42. Here, ARHGAP6 is linked to gastric cancer.