To identify synthetic lethality with RB1 loss in lung cancer cells, we selected libraries of epigenetics RNAi (siRNA library targeting 463 human epigenetics machineries with a pool of 4 siRNAs for each target) and epigenetics compounds (128 small molecule inhibitors of various epigenetics machineries) due to the functional relationship between RB1/E2F axis and epigenetics machineries in transcription regulation. Here, RB1 is linked to lung carcinoma.