TREM2 and neoplasm: Indeed, Trem2−/− mice were significantly protected from tumor progression, which was associated with high infiltration of cytotoxic lymphocytes and NK cells and reduction of dysfunctional CD8 T cells.1 Together, the INs-seq approach successfully revealed a novel marker for tumor-infiltrating immunosuppressive myeloid cells, highlighting that the INS-seq is a powerful tool that confers an important layer of information to transcriptional profiling of heterogeneous population.