TP53 and cancer: Because the A549 cell line is both p53+ and ERβ+, H1299 cells stably overexpressing FATS that were co-transfected with ERβ or p53 constructs were used to determine whether FATS also controls ODC degradation in p53-null cancer cells and to elucidate the role of ERβ, which is involved in suppressing ODC levels.