However, growing evidence has illustrated that distinct mutations in p53 can have differing properties, and some of them even exhibit tumor-suppressive features.3 As a team that previously discovered the inhibitory effects of wild-type p53 on the oncogenic WNT signaling pathway, Kadosh and colleagues proceeded to ascertain the role of mutant p53 in WNT-driven tumorigenesis. Here, TP53 is linked to neoplasm.