These factors were then included in the multivariate analysis and the result demonstrated that SPATS2 expression (p = 0.029) along with vascular invasion (p = 0.039), TNM stage (p = 0.001) and tumor multiplicity (p = 0.041) were independent prognostic prediction factors for HCC patients who received surgery (Table 2). The gene discussed is SPATS2; the disease is hepatocellular carcinoma.