ANKRD2 and head and neck squamous cell carcinoma: Our results showed that the NF-kappa B signaling pathway was the most enrichment-changed gene pathway when expression of miR-205-5p was changed in HNSCC cells, then we observed an inverse correlation between ANKRD2 mRNA or protein expression of ANKRD2 and the levels of miR-205-5p in HNSCC cell lines, and the luciferase assay results confirmed that ANKRD2 is a direct target of miR-205-5p.