To determine the downstream targets of the miR-17-92 cluster in gastric cancer progression, we performed miRNA cluster enrichment analysis and found the members of the miR-17-92 cluster were significantly enriched in several cancer-related terms, including cell proliferation, AKT pathway, angiogenesis, onco-miRNAs, and apoptosis (Fig. 6a). The gene discussed is AKT1; the disease is cancer.