These data therefore identify a subset of IL-10-regulated monocyte-derived genes, including CXCL1/2, IL1A, IL1B, INHA, IL6, CCL3/4, PTGS2, CSF2/3 and GBP1, which show a specific association for disease-associated intestinal inflammation in the RISK and GSE16879 CD cohorts. Here, PTGS2 is linked to gastroenteritis.