Together, these results demonstrate that IL-10 signalling regulates IL-23 (IL-12p40+IL-23p19+) production in a subset of CD14+ monocytes (IBD mean=3.03%, 95% CI of the mean: lower=1.11, upper=4.96; HD mean=5.32%, 95% CI of the mean: lower=3.51, upper=7.14). The gene discussed is IL10; the disease is inflammatory bowel disease.