While all subsets of IL-23p19 and/or IL-10-producing monocytes were deregulated on IL-10R blockade, monocytes isolated from patients with IBD showed decreased frequencies of IL-10+ single producing monocytes and IL-23p19+IL-10+ coproducing monocytes but not IL-23p19 single producing monocytes when compared with monocytes isolated from healthy donors (figure 3C). This evidence concerns the gene IL10RA and inflammatory bowel disease.