The inhibition of TORC1 increases the longevity of a variety of model organisms, whereas the elevated TORC1 activity has been associated with a variety of age-related diseases, including cancer, diabetes, and Parkinson's (Johnson et al., 2013; Laplante and Sabatini, 2012; Zoncu et al., 2011). The gene discussed is CRTC1; the disease is cancer.