As we had previously observed that a high SLE genetic risk score was associated with organ damage in SLE, we investigated whether this could be observed for specific pathways.5 We found that the SLE International Collaborating Clinics Damage Index was significantly higher in the SLE patients positive for the T cell or B cell receptor signalling pathways (figure 3A, B). Here, PPIB is linked to systemic lupus erythematosus.