MUC16 and ovarian neoplasm: Given the limitations of CA125 as a stand-alone diagnostic marker, the Risk of Malignancy Index (RMI) [46] and the International Ovarian Tumor Analysis (IOTA) Adnex model [47] were developed to integrate serum CA125 levels, ultrasound criteria and demographics, resulting in improved specificity and sensitivity for differential diagnosis of pelvic masses prior to surgery.