TLR3 and cholangiocarcinoma: In addition, Smac mimetic induced the degradation of cIAP1 and cIAP2 in all the cell lines examined in this study (Fig. S6A, B, C, D), while Poly(I:C) only triggered the upregulation of TLR3 in CCA cell lines, but not in MMNK1 (Fig. S7A, B, C, D).