CD4 and coronary artery disorder: As we showed that the IFN-γ response was increased in the CAD group, which is a crucial step in immunological defence against bacteria, we assessed the abundance of CD4+IFN-γ+ T cells (CD3e+CD4+ CD8a− IFN-γ+) and observed that they were increased in the spleens of CAD mice (Fig. 5i), whereas no significant differences were in the distribution of siLPL (Additional file 2: Figure S8a).