EN-RAGE, sRAGE or EN-RAGE/sRAGE yielded AUC of 0.85 (95% CI, 0.72–0.97), 0.75 (95% CI, 0.59–0.91) and 0.83 (95% CI, 0.70–0.98), respectively (Fig. 5b), in which serum EN-RAGE with highest AUC generated 68.75% sensitivity and 93.10% specificity with cutoff value 18.73 ng/ml, indicating that identified EN-RAGE has potential predicting power for AIH patients with normal ALT. The gene discussed is AGER; the disease is autoimmune hepatitis.