AGER and Cirrhosis: EN-RAGE, sRAGE and EN-RAGE/sRAGE yielded AUC of 0.65 (95% CI, 0.51–0.78), 0.82 (95% CI, 0.72–0.92) and 0.78 (95% CI, 0.67–0.90) (Fig. 5c), in which serum sRAGE with highest AUC generated 89.74% sensitivity and 60.71% specificity with cutoff value 254.61 pg/ml, suggesting that sRAGE could efficiently discriminate AIH patients with cirrhosis.