Patients with high  %MAP had a significantly higher proportion of females, a higher prevalence of hypertension, higher systolic blood pressure, higher prevalence rates of antihypertensive drug use and insulin therapy, and longer diabetes duration than those with normal  %MAP in the normal ABI group (all P < 0.001), but the same was not true in the low ABI group. The gene discussed is INS; the disease is diabetes mellitus.