We believe this has significant clinical implications with regard to the timing of glucocorticoid dosing, as patients (particularly those taking thrice-daily regimens) may be recommended to take their final hydrocortisone dose of the day in the late afternoon/ early evening and some patients with congenital adrenal hyperplasia have historically received glucocorticoids late at night to impact on the nocturnal rise in adrenal androgens in response to the nocturnal ACTH surge. The gene discussed is POMC; the disease is congenital adrenal hyperplasia.