Moreover, Xue Leng et al. observed that MIR17HG was highly expressed in glioma and participated in piR-DQ590027/ lncRNA MIR17HG/miR-153(miR-377)/FOXR2 pathway which involved in regulating the permeability of glioma-conditioned normal blood-brain barrier [23]. Here, FOXR2 is linked to central nervous system cancer.