Studied exonic mutations are mostly falling in conserved domain (49 variants) (by ConSurf) of SOD1 protein which have been found to affect the protein structure (52 variants) (by SIFT) and show deleterious effect (62 variants) (by PROVEAN) on SOD1 protein in ALS pathology (Table 5). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.