TARDBP and amyotrophic lateral sclerosis: Intriguingly, hexa-nucleotide expansion (G4C2) of C9ORF72 gene (by mean of loss or gain of function mutations leading to develop somatic mosaicism) has also been associated with fALS (with 3.2% prevalence rate in Indian ALS) which may stimulate pathology by TDP-43 accumulation, impaired RNA metabolism and defective proteosomal degradation mechanism [10–12].