Recently immunotherapy is being employed in select solid cancer management including malignant melanoma and non-small cell lung cancer (NSCLC) however in non-invasive bladder cancer it has been used for decades in the form of the Baccile Calmette-Guerin vaccine.6 While the immune system is good at detecting and eradicating tumorigenic cells through immune surveillance, established tumours employ many mechanisms to evade detection including the production of immunosuppressive cytokines and reduced surface major histocompatibility complex (MHC) expression. Here, HLA-C is linked to non-small cell lung carcinoma.