In 2010, mutations SLC52A2 (encoding RFVT2) and SLC52A3 (encoding RFVT3) were shown to cause the neurodegenerative disorder Brown-Vialetto-Van Laere syndrome (BVVL) which, therefore, designated it as a riboflavin transporter deficiency (RTD) [37]. The gene discussed is SLC52A3; the disease is renal tubular dysgenesis of genetic origin.