Lubner et al., demonstrated that entropy, mean of positive pixels, and standard deviation are inversely associated with tumor grading (p = 0.007 for entropy, p = 0.002 for mean positive pixels, and p = 0.004 for standard deviation), while skewness and kurtosis showed a trend for an inverse association with KRAS mutation (p = 0.04 for skewness, and p = 0.058 for kurtosis) [43]. This evidence concerns the gene KRAS and neoplasm.