For instance, ECFCs-induced neovascularization in a murine model of diabetic retinopathy was enhanced by the previous intravitreal injection of the adeno-associated virus serotype 2 encoding a more stable, soluble, and potent form of angiopoietin 1 known as cartilage oligomeric matrix protein Ang1 (AAV2.COMP-Ang1) [77]. Here, COMP is linked to diabetic retinopathy.