KCNK3 and neoplasm: In association with deregulated pathways, IPA identified abnormal biological functions such as the splicing of RNA, the processing of mRNA, neuronal cell death, cell survival, the proliferation of EC lines, neoplasia, and the catabolism of protein was found to be inhibited in KCNK3-knockdown hPAECs (Figure 5A,B and Supplementary Table S4b), while cell death, the metabolism of membrane lipid derivative, and the cell proliferation of breast cell line were found to be activated in KCNK3 knockdown-hPAECs (Figure 5A,B and Supplementary Table S4b).