While several clinical predictors for severe COVID-19 (dyspnea [24], old age [25], type II diabetes [26], obesity [27], possibly hypertension [28], history of cancer [29], cardiovascular disease [30], or increased ratios of CD4/CD8 [31], neutrophils/lymphocytes [32], and CRP/lymphocytes [33]) have been identified, no study has assessed clinical predictors for SARS-CoV-2 positivity. This evidence concerns the gene CD8A and COVID-19.