Immunohistochemistry (IHC) analysis of lung/mediastinal lymph node (MLN) biopsies from sarcoidosis patients show a skewed CD4:CD8 T-cell ratio of 4:1, similar to the ratio seen in tuberculoid granulomas, and bronchoalveolar lavage (BAL) fluid of sarcoidosis patients demonstrated marked lymphocytosis and an elevated CD4:CD8 ratio compared to BAL fluid of patients with different interstitial lung diseases (ILD) such as usual interstitial pneumonia, nonspecific interstitial pneumonia, and extrinsic allergic alveolitis [4,5,6]. This evidence concerns the gene CD4 and interstitial lung disease.