Additionally, a similar Chinese study on one family with three members diagnosed with sarcoidosis reported mutations in the monocyte chemoattractant protein-1 gene (MCPIP1), a transcription factor that works through mTORC1 signaling, resulting in negative effects on TH17 differentiation—further linking TH17 cell dysfunction to sarcoidosis pathogenesis [91]. This evidence concerns the gene ZC3H12A and sarcoidosis.