CD4 and sarcoidosis: The inflammatory cytokines TNF-α, IFN-γ, Macrophage Inflammatory Protein (MIP)-1α, and IL-12 were all elevated in the BAL fluid of sarcoidosis patients, indicating a pro-inflammatory state as well as a shift toward the TH1 subtype of CD4+ T-cells and the classically activated M1 macrophages that TH1 cells promote [8].