IL-6, a cytokine that activates the main TH17 transcription factor STAT3, has significantly increased mRNA levels in sarcoid granulomas compared to suture granulomas, while IFN-γ, a TH1 cytokine induced by STAT4 and which activates STAT1, has increased mRNA levels in sarcoid granulomas compared to suture and fungal granulomas [87]. This evidence concerns the gene IFNG and Granuloma.