Because non-Löfgren’s syndrome sarcoidosis patients only exhibited a higher CD8+ T-cell-mediated lysis rate upon pre-stimulation by IL-2, it can be assumed that these sarcoid CD8+ T-cells lacked IL-2 beforehand—supporting the concept that inadequate TH1 cell stimulation is the culprit [67]. The gene discussed is CD8A; the disease is sarcoidosis.