Among the tumor specimens with IDH mutation, mRNA levels of SEMA3B, SEMA3C, SEMA3D, SEMA3G, NRP2, PLXNA2, and CDH1 were significantly higher (p < 0.05), while SEMA3F, NRP1, ITGB3, ITGA5, and VEGFA genes were under-expressed (p < 0.05). The gene discussed is PLXNA2; the disease is neoplasm.