Lower mRNA expression of SEMA3B, SEMA3D, SEMA3G, and PLXNA2 or higher mRNA expression of SEMA3F, NRP1, ITGB3, ITGA5, and VEGFA genes were detected in the older patient group and associated with the higher tumor grade, wild-type status of IDH, and lower rate of survival time (p < 0.05). Here, SEMA3D is linked to neoplasm.