In relation to the malignancy grade of the tumor, mRNA levels of SEMA3B, SEMA3C, SEMA3D, SEMA3G, PLXNA2, and CDH1 decreased while mRNA levels of SEMA3F, NRP1, ITGB3, ITGA5, and VEGFA increased with the increase of the tumor malignancy (p < 0.05) (Table 1). Here, ITGA5 is linked to neoplasm.