To evaluate the relationship between patient clinicopathological factors (gender, age until operation, glioma malignancy grade, methylation of MGMT, and mutation status of IDH), and patient overall survival (OS), as well as to determine survival-related genes, an univariate Cox proportional hazard regression analysis was performed on expression data of 19 SEMA3 signaling genes. Here, MGMT is linked to central nervous system cancer.