Lower mRNA expression of SEMA3B, SEMA3D, SEMA3G, and PLXNA2 or higher mRNA expression of SEMA3F, NRP1, ITGB3, ITGA5, and VEGFA genes were detected in the older patient group and associated with the higher tumor grade, wild-type status of IDH, and lower rate of survival time (p < 0.05). The gene discussed is PLXNA2; the disease is neoplasm.