SMAD3 hypomethylation is commonly observed in several clinical parameters, such as age, ethnicity, sex, tumor type, tumor stage, tumor size, regional lymph node metastasis, distant metastasis, differentiation grade, vascular invasion, location, microsatellite instability (MSI), and kirsten rat sarcoma viral oncogene homologue (KRAS) mutation. Here, SMAD3 is linked to metastatic malignant neoplasm in the lymph nodes.