PLOD1 and Familial prostate cancer: The extended suppression of LH produced by the PEG-modified aptamer, and the absent immunogenicity of NOX 1255 and NOX 1257 (in rabbits), makes these aptamers suitable agents for use in research (where GnRH-mediated pathways are being investigated) and as therapeutic agents (such as in assisted fertility cycles where endogenous LH suppression is required and in prostate cancer to produce androgen suppression).