Abnormal LH pulsatility is also present in Polycystic Ovarian Syndrome (PCOS, which affects up to 13% of women of reproductive age) and is characterised by at least two of the following features: hyperandrogenism, polycystic ovarian morphology on ultrasound and/or oligomenorrhea/amenorrhea [14]. Here, PLOD1 is linked to polycystic ovary syndrome.