Resveratrol has various mechanisms of action including (1) reduction of intracellular ROS, (2) activation of sirtuin 1 (SIRT1), a histone deacetylase that increases DNA stability, prolongs survival in mammals, and provides cellular protection against UV radiation through p53 and c-Jun n-terminal kinase (JNK) pathway modulation, (3) significant cancer chemopreventive potential. Here, SIRT1 is linked to cancer.